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It can also lead to irreversible degradation or a complete loss of therapeutic potency
Maher, P
Originally developed to help manage type 2 diabetes, semaglutide has shown promise in aiding weight loss efforts even in patients without diabetes
4,6 A key issue in the physiology of type 2 diabetes (T2DM) is the reduced incretin effect, which mainly results from decreased activity of the primary incretin hormones, GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic peptide)
Even more encouraging, tirzepatide was associated with reduced urine albumin-to-creatinine ratio (UACR) after 24 weeks, sustained through week 72, without detrimental changes to estimated glomerular filtration rate (eGFR)
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